Statins may have no effect on exercise pain

In the journals

A common complaint among statin users is that the cholesterol-lowering drugs increase pain during and after exercise. A study published April 11, 2023, in the Journal of the American College of Cardiology counters this perceived connection. Researchers recruited 100 people (average age 65). Two-thirds were taking statins, mostly simvastatin (Zocor) or atorvastatin (Lipitor). The group participated in a walking event in which they trekked either 18, 25, or 31 miles on each of four consecutive days. Muscle pain, fatigue scores, and levels of enzymes associated with muscle injury were measured before and after the event. The researchers found that pain, fatigue, and enzyme levels increased similarly for all participants whether or not they took statins or had existing muscle pain.

According to the researchers, the new findings suggest that the drugs won't exacerbate usual pain symptoms from moderate-intensity exercise.